📑 Landmark Stroke Trials

🩸IV Thrombolysis

• Retrospective (2015)

• Retrospective (2010)

🩸DAPT for high-risk TIA and minor stroke

• Editorial (NEJM, 2023)

  • Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) (2013) 🇨🇳

  • Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) (2018) 🌐

  • The Acute Stroke or Transient Ischaemic Attack Treated with Ticagrelor and ASA for Prevention of Stroke and Death (THALES) (2020) 🌐

  • Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke (ARAMIS) (2023) 🇨🇳

  • Intensive Medical Therapy for High-risk Intracranial or Extracranial Atherosclerosis (INSPIRES) (2023) 🇨🇳

🩸Anticoagulation for Afib after stroke

• Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation (ELDERCARE-AF) (2020) 🇯🇵

• Early versus Later Anticoagulation for Stroke with Atrial Fibrillation (ELAN) (2023) 🌐

🩸Statins

• Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) (2006) 🌐

• Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein (JUPITER) (2008)

• Treat Stroke to Target trial (2019) 🌐